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Leon Lab @ UCF

Leon Lab @ UCF

Biomolecular Engineering
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Research in the biomolecular engineering lab lies at the intersection of biomaterials and polymer science, where we use biomimetic approaches to create dynamic materials. We are focused on expanding the self-assembly toolbox to include multiple, synergistic molecular interactions using biomolecules, particularly peptides and peptide/polymer conjugates which can incorporate many distinct functionalities arising from individual amino acids. By leveraging multiple orthogonal molecular interactions, we want to recreate the flexibility, adaptability, and multivalency found in natural biomaterials that lead to their dynamic nature.  Currently we apply this approach to the design of delivery vehicles for nanomedicine, the investigation of the molecular interactions that lead to intracellular liquid-liquid phase separations, and directing the growth and assembly of inorganic nanoparticles.

Polyelectrolyte Complex Micelles

Nanomedicine

Polyelectrolyte Complexes

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