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Sudipta Seal’s research has developed surface engineered nanoscale transition metal and rare earth oxide ceramics for catalysis, energetics and nano-biomedicine. He has developed scalable methods for template free nano oxide particles. He engineered nanoceria with switchable valence states with regeneration capability. Besides he applies various surface chemical tools to understand the surface physics of nanostructures. Finally, his fundamental research is translated to applications, from wound healing, cancer healing, tissue regeneration, COVID-19, solid fuels, solar materials, semiconductor films, sensors, AI/Machine Learning, etc. His research has led to various licenses and startups.


Seal discovered the antioxidant properties of nanoceria by controlling defect chemistry. Featured in BBC news, New York Times and won prestigious grant from USA-NSF, NIH and DOD. Further, these nanostructures were developed into electrochemical peroxide regenerative sensors. Seal believes that the unique structure of nanoparticles, with respect to valence and oxygen defects, promotes, cell longevity by scavenging superoxide radicals produced in excess in cellular matrix and regenerate stem cells. Further protection was observed in rat retina and prevent the loss of vision, and other blinding diseases. (NATURE Nanotechnology. The research has led to the commercialization of the technology through creation of Startups NanoCe LLC. Currently received funding to work with FDA for pre-clinical trial. This is a real impact from lab to bench side. The technology is further licensed to a startup BioCurity LLC and others to advance the commercial use of nanoceria in cancer therapy. Seal’s experimental work is supported by theoretical studies for a wide range of disciplines spanning from solar energy, energy harvesting and fundamental science of chemically active defect engineered oxide nanoceramics.

His novel surface engineering of oxides/ceramics has led to the creation of a Zerocrete product, creation of nSolgel Startup. Recently they have developed a product named OOPS (Oil Optimized ceramic Particle Surface under a NSF RAPID grant (Gulf of Mexico Oil Spill) subsequently highlighted in National Geographic Article: (Seeking a Safer Future for Electricity’s Coal Ash Waste.

Fundamental Science

Shown for the first time using Aberration Corrected High Resolution Transmission Electron Microscopy atom hopping in Nano cerium oxide and explain their unusual bio catalysis properties. Various relevant patents are awarded in this area and led the development of a startup company NanoCe LLC for technology commercialization. Various Nanoceria formulations are also developed to prevent damage of the photoreceptor cells and other neurodegeneration, protection of healthy cells from radiation, patents are awarded and licensed.

Energetics Research

Seal’s group has recently developed tailored nano additives (surface modified ceramics) for nanoenergetics. A former Ph.D. student from the group has created a startup Helicon Chemicals to further license the technology from UCF and in the last two yrs this startup has won various SBIR Phase I and II awards incorporating these nanomaterials in actual solid propellants (formulation) in real scenario testing environment in collaboration with US DOD. The main goal of this company to scale up these nano oxide energetic materials for further rocket fuel applications, which is currently underway. Controlled nanoceramics (zirconia, YSZ), solgel derived oxides and chalcogenide glasses and their properties are documented in various high impact articles in Nano Letters, Progress in Materials Science and the Journal of the American Ceramic Society, etc. Based on above achievements, Dr. Seal has received the Central Florida Engineer of the year award and recently awarded the prestigious Schwartz Tech Award by Orlando Economic Development authority for translating research into technology commercialization.

Rare Earths for Biomedical Applications — Nanobiotechnology
Seal’s group has been at the forefront of exploring the redox active nature, auto-regenerative, radical scavenging properties and the valence structure of the rare earth cerium oxide when it is present in the nanocrystalline form. By scavenging of the excess reactive oxygen species, these cerium oxide nanoparticle (also called as nanoceria as they are synthesized in the size range of 3-5nm), are able to eliminate the oxidative stress and balancing the cellular oxidative environment and making it more homogenous. In a similar direction, the group has conjugated the highly antioxidative nanoceria with a variety of biomolecules towards its biomedical application. In a similar study, this nanoceria is conjugated it with a small RNA molecule, also known as microRNA molecules which have been to find to play a significant role in regulating the inflammatory response. All together these conjugates have been used towards the diabetic wound healing. The conjugate helps to decrease the inflammation and the oxidative stress resulting in the correction of impaired healing and overall improving the biomechanical properties of healed skin.

Seal’s group further interests are also in the development of nanoceria based anti-inflammatory coatings and its successive application in the development of upcoming prosthetics.
Plasma-Based Nano Manufacturing
Durip ONR Plasma NanoManufacturing Lab The thermal spray laboratory at UCF houses the state-of-the-art coating and bulk component development facility comprising Plasma and HVOF spray modules. The laboratory is well equipped to develop coatings from ceramic, metallic particles (both micro and nano-size ranges) and solution precursors with applications spanning from corrosion-wearoxidation resistant, a thermal barrier to thermal protection. The laboratory also has the expertise to manufacture bulk nanostructured composites with simple to complex geometries with considerable ease than other processing techniques. Depending on the material and coating/ bulk component properties, the torch and spray parameter combination is chosen from the thermal spray infrastructure. Using a range of plasma spray torches 3 MB (40 kW), 9 MB (80 kW), F4 (60 kW), SG100 torches, the high melting point materials could be processed. HVOF torches (Jet Kote) is useful to shoot the metallic particles at high velocities thereby high dense overlay coatings could be achieved on desired substrates. The torches are mounted on a six-axis robot that could carry the torch to virtually any location in the booth precisely to perform the coating process precisely. Sensors (DPV, Acura Spray, Spray Watch) are available to determine the velocity and temperature of particles during the spray process that can be used to correlate the spray parameters to the particle states and thereby the properties of the end application. Powder feeders (1264 Praxair model and DJ 9MP) and mass flow controllers are available for precise monitoring of the feed rates of powders and gases respectively. Spray drying equipment is available to prepare nano-feedstock powders for effective and safe handling of nanopowders for coatings and components for thermal, catalytic, biomedical and energy applications.

A few examples of our work:

High-Temperature Oxidation Resistance coating using solution precursor plasma spray: Solution precursor plasma spray (SPPS) is used to deposit nanoceria coating on steels. In-house material characterization facility is available to study the microstructure and the surface chemistry using thermodynamic calculations, X-ray photoelectron spectroscopy (XPS), TEM, SEM, FIB, RAMAN, and XRD. Cyclic oxidation at 10000C revealed excellent corrosion resistance of the steel in presence of the SPPS-processed nanoceria coating.

Spray drying of nano alumina and ceramic particles to facilitate plasma spray: Spray drying has been successfully utilized to agglomerate the nanoparticles to facilitate the handling and uniform melting of the agglomerates during the spray. The process variables could be optimized to achieve narrow size agglomerates with a mean size of 25 μm that could be easily fed through the plasma torch and achieve a nanostructured coating. The spray could be optimized to achieve agglomerates of any nanoparticles that have virtual merits with retained nanostructures in the final coating from the point of view wear resistance, high thermal cycles to failure and low thermal conductivity.

Bulk Nanocomposites: Freeform bulk nanocomposites with ceramic and metal matrices with complex geometries have been developed that requires no machining. Some of the properties that have been achieved are high-temperature oxidation resistance using MoSi2-Si3N4, high elastic modulus using W-HfC, high fracture toughness (5 MPa.m1/2) Ni-Alumina, increase ductility in nano-micro alumina, high fracture toughness Carbon nanotube-Alumina, TaC composites, Al-Si alloys, and nano Al-Si components and many others for a variety of high temperature and aerospace applications.

Nanostructure Sensor System for Chemical and Biological Detection We are exploring the chemical-resistance properties of semiconductor oxides for developing gas sensor by integrating into a MEMS device. Our devices are highly sensitive and selective and can operate in low temperature and high humid conditions. Detailed material characterization is performed to understand the surfaces of these nanosensors. We are also developing bio-sensors, where the redox property of nanocrystalline cerium oxide is utilized to detect and measure the production of hydrogen peroxide in the biological environment. This has implication in detecting ROS in various neurodegenerative, cardiac, and metabolic disorders. Research is focused on the surface modification of these nanocrystalline detection elements to prevent sensor ‘bio-fouling’ through protein deposition.

Using the ordered nature and affinity of bio-molecule pairings, technologies are being produced to identify and quantify disease biomarkers in a number of biological systems/models. Device platforms rely on the highly selective and sensitive binding between protein/bio-molecules and specific aptamers or antibodies modified nanomaterials. These platforms are currently being integrated into multi-channel, multiplexed devices (e.g. micro-fluidic, organic electrochemical transistors) to analyze complex bio-media: allowing concurrent, real-time measurements of different analytes from low sample volumes.
High Temperature Corrosion High temperature and high pressure (HT/HP) corrosion test setup have been designed within situ electrochemical impedance spectroscopy (EIS) capability. The cell can be operated at high pressure (20000 Psi) and high temperature (300 oF) in corrosive conditions, which provides important corrosion information of various steels and materials in HT/HP conditions useful to oil and gas industries.

Atomistic Simulation We have revealed novel radiation-sensitive properties of ceria nanoparticles. To understand this, the group is working out an atomistic simulation to understand the interaction of radiation-induced changes in nanocrystalline cerium oxide. Various lattice models are created for cerium oxide and study the effect of radiation by carrying out molecular dynamics simulation. The simulation study is underway in collaboration with the team at Pacific Northwest National Lab. (International partners: Cranfield University)
Current funded research in Seal Research group & Active Interdisciplinary Collaboration
    1. Materials for Lunar and Aesteroids research: Visit ( Funding:
    2. Nanoparticle mRNA research on wound healing: Funding
    3. Composites for Space Applications: Funding:
    4. Understanding damage in QCL laser material: Funding
    5. Multi purpose Imaging XPS: Funding
    6. Multi purpose Environmental XPS: Funding
    7. Capture and Kill coatings for PPE in COVID 19: Funding
    8. Next generation disinfectants for COVID 19: Funding
    9. Ecocrete development: Funding
    10. Composite study: Funding
    11. AI/ML research on COVID 19
    12. Semiconductor research: Funding
    13. Fog Sensor research: Funding
    14. Energetics research:
    15. Solar Energy research: soon to be established
    16. Materials research for Titan moon mission: soon to be established:
    17. Active biomedical research with College of Medicine: