Aleksandra A. Petelski-Kulik earned her Ph.D. in bioengineering from Northeastern University, and her bachelor’s in biomedical engineering and master’s in materials engineering from Stevens Institute of Technology. During her doctoral training in the Slavov Laboratory, Aleksandra gained experience in mass spectrometry proteomics by contributing to the development of the lab’s single-cell proteomics methodology (SCoPE2), which then she applied towards early mammalian development. With a keen interest in making single-cell proteomics more accessible, Aleksandra co-founded Parallel Squared Technology Institute, a non-profit research organization dedicated to drastically scaling up the throughput of MS proteomics without sacrificing accuracy. At UCF, Petelski aims to exploit the heterogeneity of single cell proteomes towards building better materials for biomedical applications. 

• Single-cell analysis
• Proteomics
• Mass spectrometry
• Bioinformatics
• Systems biology

• Galatidou, S., Petelski, A.A., …Barragan, M. (2024). Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes. Molecular Human Reproduction, 30. https://doi.org/10.1093/molehr/gaae023
• Gatto, L., … Petelski, A.A., … Slavov, N. (2023). Initial recommendations for performing, benchmarking and reporting single-cell proteomics experiments. Nature Methods, 20, 375 – 386. https://doi.org/10.1038/s41592-023-01785-3
• Huffman, R.G., … Petelski, A.A., … Slavov, N. (2023). Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics. Nature Methods, doi: https://doi.org/10.1038/s41592-023-01830-1
• Petelski, A.A., Slavov, N., & Specht, H. (2022). Single-cell proteomics preparation for mass spectrometry analysis using freeze-heat lysis and an isobaric carrier. Journal of Visualized Experiments, doi: 10.3791/63802-v
• Petelski, A.A.*, Emmott, E.*, … Slavov, N. (2021). Multiplexed single-cell proteomics using SCoPE2. Nature Protocols, 16, 5398 – 5421. https://doi.org/10.1038/s41596-021-00616-z
• Specht, H., Emmott, E., Petelski, A.A., … Slavov, N. (2021). Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2. Genome Biol, 22, 50. https://doi.org/10.1186/s13059-021-02267-5
• Kastan, N., Gnedeva, K., Alisch, T., Petelski A.A., … Hudspeth, A.J. (2021). Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues. Nature Communications, 12, 3100. https://doi.org/10.1038/s41467-021-23395-3
• Petelski, A.A. & Slavov, N. (2020). Analyzing ribosome remodeling in health and disease. Proteomics, 20, 17-18. https://doi.org/10.1002/pmic.202000039

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